Much like their Moto3 colleagues before them, the premier class were in no rush to improve their FP1 times, while nearly inseparable within the top ten. Takaaki Nakagami was the first rider to surpass his own FP1 benchmark as the Japanese rider anticipated the time attack. However, Jack Miller reclaimed his title of Friday King of Valencia, although in much improved conditions this time, going nearly a tenth of a second faster than Nakagami in the final minute of the session. Pecco Bagnaia surprised as he joined the top three as lead Ducati.
Pol Espargaro added a KTM to the mix in fourth position, ahead of early session leader Johann Zarco. Andrea Dovizioso maintained a solid position in the top six six tenths off top spot and closely followed by Cal Crutchlow. Alex Rins in eighth place also provisionally secured a Q2 position, while Aleix Espargaro in ninth had no such luck on the combined standings. Maverick Vinales rounded out the top 10 of the session, as well as in the overall hierarchy, while the remaining Q2 ticket is provisionally held by Franco Morbidelli, although the Italian was 13th fastest in the session.
Championship leader Joan Mir had a more challenging FP2, the Spaniard making a rare mistake that saw him slide out at turn 4 in the final 10 minutes of the session. Mir managed to rejoin the time attack on his second machine but could not do enough to re-enter the top 10. The likes of Fabio Quartararo and Valentino Rossi did not feature much at the business end but both Yamaha men seemed to be focusing on race pace rather than fast laps. Despite ending FP2 in 19th position after two harmless crashes at turns 2 and 4, Alex Marquez was only seven tenths of a second slower than the leader.